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Moreover, the 2017 Cell paper revealed FOXO4-DRI was able to lower the cellular senescence induced by chemotherapy treatment Doxorubicin: doxorubicin-induced senescent cells showed an upregulation in FOXO4 foci and FOXO4-DRI potently and selectively lowered the viability of doxorubicin-senescent versus control IMR90

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Mitogen-activated protein kinase The mitogen-activated protein kinase (MAPK) cascades are major intracellular signaling pathways that regulate various cellular processes, such as proliferation, differentiation, and stress response