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The ammonia will exert a direct toxic effect on the neurotransmission responsible for part of the neurological symptomatology

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Similarly, people with cystic fibrosis often have weight loss due to malabsorption of nutrients, along with intestinal inflammation

In brief, chemical standard libraries of 149 metabolites in seven pooled libraries were prepared and serially diluted in high-performance liquid chromatography (HPLC)-grade water from in a dilution series from 5 mM to 1 M to generate external standard pools, which are used for calibration of isotopically labelled internal standards and to quantify concentrations of metabolites for which internal standards were not available