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In the first study, postmenopausal women receiving Pt-141 experienced significant weight loss and an average decrease in daily caloric consumption (400 kcal/day) compared to the control group

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Previous studies using the liver cancer cell line HepG2 under normoxic or hypoxic conditions showed that melatonin reduces VEGF expression by disrupting physical interaction between phosphorylated STAT3, HIF-1, and transcriptional coactivator/p300/CBP on the VEGF promoter

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