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These effects were further amplified when GSH-depleted cells were treated with ASA

Selective Gsto2 knockdown prevents the early and late onset of motor symptoms in Trkb Penk -KO mice Penk -KO The above results suggest that disrupted TrkB signalling in iSPNs affects GSHascorbate metabolism, particularly GSTO2, which impacts the DA system and thus energy metabolism

The story of these diverse experimental drugs is eerily similar

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