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The above notion could reconcile the paradox of EBV exposure being a strict requirement for subsequent development of MS, and on the other hand the recent failure of an EBV-specific T-cell therapy (Giovannoni et al., 2024): if early EBV infection triggers a molecular cascade driving MS pathogenesis that no longer requires replication of virus, anti-viral therapies begun once MS is clinically evident may be doomed to failure

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Ipamorelin binds to the receptor for the hormone ghrelin and activates it