In rodents, repeated administration of andrographolide (100 mg/kg) induces liver and kidney injuries, manifested as elevated ALT and AST levels and renal tubular edema
Several reduced mortality and neurological deficits in mice without reducing bacterial clearance a critical finding, because any anti-inflammatory therapy that also impairs the host's ability to kill bacteria could make outcomes worse even if it reduces short-term inflammation, as Cincinnati Children's press release explains
They are aimed at somewhat different priorities: retatrutide for maximum weight loss, survodutide for a combination of weight loss and liver disease
Fever Anorexia, lethargy Weight loss Muscle pain, hyperesthesia Respiratory tract disease Conjunctivitis Rhinitis Coughing Respiratory distress, tachypnea Diffuse harsh lung sounds Vomiting, diarrhea Abdominal discomfort Icterus Abdominal effusion Arthritis, joint pain, shifting lameness Cardiac arrhythmias, sudden death Splenomegaly Lymphadenomegaly Pyogranulomatous dermatitis Neurologic signs Ataxia Circling Behavioral changes Twitching Tremors Ocular signs Retinochoroiditis, retinal hemorrhages Optic neuritis Optic nerve atrophy Anisocoria Blindness Anterior uveitis, aqueous flare, hyphema, velvety iris Glaucoma Lens luxation Retinal detachment Neonatal disease (after transplacental transmission) Stillbirth Fading kittens Organ dysfunction Liver: hepatomegaly, icterus, ascites Lung: respiratory distress Central nervous system: excessive sleep, crying Adapted from Dubey JP, Lappin MR: Toxoplasmosis and neosporosis
