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In theory, this could make the transition smoother for GI effects related to GLP-1 and GIP, while the glucagon-mediated effects (thermogenesis, increased heart rate) would be entirely new

In a larger study of mice expressing HIP, no evidence of pancreatitis was seen in mice given sitaglyptin for 1 year (4)

Ratziu V, Charlotte F, Bernhardt C et al (2010) Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial

The clinical dosing protocol starts at 2.5 mg/week and escalates through 5, 7.5, 10, 12.5, and 15 mg/week