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Table of Contents Week 1: Nothing Visible Weeks 2-3: Subtle Internal Shifts Weeks 4-6: First Visible Changes Weeks 6-8: Peak Effect Window Weeks 8-12: Continued but Diminishing Returns Factors That Affect Results By Use Case When to Adjust Protocol Related Reading References Week 1: Nothing Visible What's happening internally: AOD-9604 begins activating lipolysis through the beta-3 adrenergic receptor pathway

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This change will resolve a cost inversion in CMHC cost data that resulted in higher geometric mean costs for 3-service days than for 4-service days