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Ebselen was found to increase the expression of GPX1 in SGNs after peroxynitrite damage, which is consistent with the reports that ebselen can increase the expression of GPX1 in cochlea after electrical stimulation ( gpx1 / mice leads to the aggravated SGN injury (cell loss and apoptosis) induced by peroxynitrite, although it might cause no effect on SGN development as SGNs presented normal morphology and cell number in gpx1 -deficient mice
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Each manufactured lot is third-party analyzed with documentation of HPLC purity, ESI-MS identity, chiral purity, optical rotation, residual moisture, and heavy metals
They are usually less expensive than brand-name drugs because they do not have to repeat the costly clinical trials conducted by the original manufacturer
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