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While Novo Nordisk and Eli Lilly are now competing with each other with GLP-1 pills, Pfizer is still trying to get a GLP-1 drug out the door

438,439 GLP-1 can also enhance endothelial function by promoting the production of NO, possibly through activating eNOS, thereby affecting vasodilation, anti-inflammatory actions, and anti-atherosclerosis

Alleviation of depression by glucagon-like peptide 1 through the regulation of neuroinflammation, neurotransmitters, neurogenesis, and synaptic function

But the theory is supported by basic receptor pharmacology principles that apply across all G protein-coupled receptors