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At higher doses, some concern exists about pro-inflammatory effects: LL-37 can activate NF-kB pathways, potentially worsening certain inflammatory conditions

doi: 10.3390/ijms22052301, 109

The FDA also warns consumers about misleading claims regarding the safety and effectiveness of unapproved stem cell products

unlike some other GHS peptides, ipamorelin does not significantly elevate levels of cortisol or prolactin, which reduces unwanted side effects like increased appetite, water retention, or mood swings