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Ilanne-Parikka P, Eriksson JG, Lindstrm J, Hmlinen H, Keinnen-Kiukaanniemi S, Laakso M, Louheranta A, Mannelin M, Rastas M, Salminen V, Aunola S, Sundvall J, Valle T, Lahtela J, Uusitupa M, Tuomilehto J

Each time a cell divides, telomeres shorten, eventually triggering cellular senescence or apoptosis - effectively limiting the replicative lifespan of normal somatic cells to approximately 50-70 divisions (the Hayflick limit)

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At 8 weeks post-infection, the percent of lung involvement in granuloma formation of the untreated mice increased to an average of about 60% (Figure 8B)