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Now, however, it is recognized that these RBC contain a coagulum of hemoglobin which has separated from the membrane, often leaving an unstained non-hemoglobin-containing cell membrane (i.e., having the appearance of a bite removed from the cell)

Furthermore, the functional assessments of lower limbs of mice, including the reflexive mechanical pain-related responses experiment 34 and thermal pain-related responses experiment 35 , were conducted using the von Frey test and hot plate test, respectively

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