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Collectively, these findings support the notion that LPCAT3 serves not only as a core lipid remodeling enzyme in the ferroptosis cascade but also as a disease-specific modulator of immune-metabolic interactions in OA

However, and this is a massive 'however', getting this approval is a difficult, often moving-target objective

45,46 As shown in Figure 2 , GLP-1RAs penetrate the blood-brain barrier and directly activate GLP-1 receptors in the hypothalamus, especially within the ARH nucleus, a key center for appetite regulation