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Semaglutide 2.4 mg (Wegovy) : A once-weekly injectable GLP-1 receptor agonist approved by the MHRA for chronic weight management

This timeframe coincides with the body's adaptation to the medication's effects on gastric emptying, appetite, and glucose regulation

Thus, development of orally active small molecule GLP-1R modulators remains an attractive strategy and a few compounds have progressed to clinical trials 8