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Key Points Ozempic should be refrigerated (36F46F or 2C8C) before first use to maintain its effectiveness After first use, Ozempic can be kept at room temperature (up to 86F or 30C) for up to 56 days Never freeze Ozempic pens or expose them to temperatures above 86F If an unopened Ozempic pen is accidentally left at room temperature for less than 24 hours, it's likely still safe to use If you've recently been prescribed Ozempic for type 2 diabetes or weight management, you probably have questions about how to store it properly