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More research is needed to fully understand this relationship.

While PIONEER 6 demonstrated cardiovascular safety (non-inferiority), and the SOUL trial reported significant reductions in MACE, the oral formulation does not yet carry a formal FDA indication for cardiovascular risk reduction in high-risk adults with type 2 diabetes

Given that proline and hydroxyproline together account for approximately one-third of collagens amino acid content, increased proline biosynthesis is now considered a key metabolic driver of fibrotic remodeling [13,14,15,16]

Fifty-seven percent were male, 85.1% were Caucasian, 4.7% Black or African American, and 4.7% were Hispanic