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Acknowledgement The authors would like to acknowledge that the Graphical Abstract was created using BioRender.com and the linguistic correctness was checked and corrected by Instatext

A.von FrankenbergA

When consuming the same amount of folic acid, people with the MTHFR 677 TT genotype (two copies of T, one copy from each parent) have on average 16% less folate in their blood than people with the MTHFR 677 CC genotype (two copies of C)