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Unlike linear pathways, the TCA cycle operates in a cyclic manner, with oxaloacetate serving as both the initial material for citrate synthesis, catalyzed by citrate synthase and the final product, produced by malate dehydrogenase, ensuring continuous renewal of the cycle

Notably, supplementation with ferrostatin-1 or trolox, both of which are radical-trapping antioxidants and potent inhibitors of ferroptosis, rescued survival but not proliferation under cystine-free conditions (Extended Data Fig

In addition to limiting lipid absorption, directly inhibiting FAO represents a promising therapeutic approach