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The investigators reported that Epithalon induced telomerase activity in cultures that were previously telomerase-negative, with corresponding increases in telomere length, and concluded that the peptide may extend cell-population lifespan through anti-senescence activity [1]

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However, the sub-pocket for the TYS of CCK-8 is more positively charged in CCK1R attributed to N98 2.61 , and R197 ECL2 contributes to a beneficial chargecharge interaction with TYS of CCK-8 (Fig