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From this perspective, MDR manifests biologically and clinically as four highly intertwined evolutionary subtypes: Firstly, de novo(primary) resistance, where tumors inherently harbor resistance mutations or exist in a profoundly immunosuppressed state, exhibiting absolute non-response from the initial treatment phase [14]

In the U.S., the Centers for Disease Control and Prevention reports more than 100 million adults, or about 42 percent of the population, are living with obesity, accounting for $173 billion in medical expenditures

doi: 10.1007/s00125-022-05773-8 18 PeronardRMayntzS

Gurung M, Li Z, You H, et al