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They must follow United States Pharmacopeia standards for sterile compounding but are not required to register with the FDA or follow the same Current Good Manufacturing Practices (cGMP) that pharmaceutical manufacturers must meet
As well, pro-inflammatory cytokines such as IL-6 and TNF- are elevated in PD
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These characteristics originally made it an important subject in gastrointestinal research before its investigation expanded into connective tissue and regenerative biology
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