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As many cysteine-containing proteins (transporters, receptors and enzymes) at extracellular surfaces or in extracellular fluids are prone to oxidation, their activity might be influenced by the thiol/disulphide redox microenvironment

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In summary: Evaluating SMM loss plausibly due to GLP-1 medications compared to weight loss through other interventions (without GLP-1 medications), we find a dearth of evidence of disproportionate muscle mass loss