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Delanty N, Dichetr MA

The metabolic effects that promote glucose uptake acutely can, with chronic exposure, lead to cells becoming less responsive to insulin's signals

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In addition, GLP-1 RAs may reduce accumulation of amyloid precursor protein, improve cognitive function, increase proliferation of neuronal progenitor cells, and attenuate neuronal damage postischemia, in Alzheimer disease and Parkinson disease (PD)