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This article outlines an approach to interpreting and working up a high serum B12 in adults by separating four possibilities: intake-related elevation, disease-associated hypercobalaminemia (an elevated blood B12 associated with an underlying condition), analytical interference, and functional deficiency

Weight loss alone can enhance mood and increase feelings of hope and possibility, and research shows that people often experience fewer depressive symptoms during the first year after significant weight loss

This is a key consideration in any poly-substance research protocol

Wu W, Li W, Chen H, Jiang L, Zhu R, Feng D