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Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid

A peer-reviewed overview in the International Journal of Molecular Sciences (Araj et al., Medical University of Warsaw, 2025) establishing Epithalon as a highly bioactive pineal tetrapeptide with documented mechanisms spanning telomere maintenance, epigenetic regulation, antioxidant defense, immune recalibration, and circadian rhythm restoration provides the scientific framework for all five mechanisms described in this section

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Microbiota-mitochondria inter-talk: consequence for microbiota-host interaction