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Since then, GLP-1 RAs have attracted considerable academic interest, leading to the continuous introduction of innovative analogs into the pharmaceutical industry
It is also possible that GLP-1 receptors within the brain are activated by circulating GLP-1 produced in the periphery [14]
However, long-term microdosing strategies have not been studied in large randomized controlled trials
GLP-1 RAs not only ameliorate insulin resistance and microvascular injury [84], which are significant determinants of depression in T2DM, but also enhance dopamine metabolism and stimulate growth factor signaling pathways, suggesting potential neuroprotective functions [85,86]
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