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The SURMOUNT-1 DXA substudy (Look et al., 2025) showed that tirzepatide reduced lean body mass by 10.9% over 72 weeks, compared to 2.6% with placebo

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To test if the specific amino acid changes at the DPP-4 cleavage site in pGLP-1 and eGLP-1 result in resistance to degradation, we compared their cleavage to that of human GLP-1 (hGLP-1) and the DPP-4 resistant exendin-4 (Ex-4) (Fig

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