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These preclinical results were supported by genome-wide association studies, which have identified variants with reduced activity at the human GIP receptor locus that are associated with reduced BMI [72]

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These lipid hydroperoxides are unstable and can decompose into secondary oxidative products, such as aldehydes, alkanes, and ketones, with malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) being notable for their cytotoxic and mutagenic effects [51]