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Probiotics are generally safe, but over-supplementation or imbalances in strains like Akkermansia and Bifidobacterium could theoretically lead to unintended effects, including microbiome disruption

If confirmed, these medications could represent an important new tool in the treatment of substance use disorders

Diary cards were provided to participants on days 1, 7, 14, and 21, onto which participants were instructed to record their temperature, adverse events (AEs), medication, and supplementation

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