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SURMOUNT-4 and STEP trials reveal around two-thirds of GLP-1induced weight loss returns within a year, mirroring normalized regain rates in diet-exercise studies

10.1128/MCB.25.7.2795-2807.2005 53 El FatimyR.LiS.ChenZ.MushannenT.GongalaS.WeiZ.et al

And if youre going to do that every two or three years, thats taking a huge toll off even the skill that you could develop and your maximal capacity at that