Participants in a clinical trial who took the highest dose of Lillys orforglipron lost 11.2% of their total body weight on average over nearly 17 months, compared with a 2.1% loss in those who took a placebo
[DOI] [PubMed] [Google Scholar] 11.Bae J.C., Lee W.Y., Yoon K.H., Park J.Y., Son H.S., Han K.A., Lee K.W., Woo J.T., Ju Y.C., Lee W.J., et al
You should contact your GP if you experience: Urination that is painful or burning (which may suggest a urinary tract infection see the NHS UTI page for guidance) Blood in the urine (haematuria), which always warrants prompt medical review Excessive thirst alongside very frequent urination, which can be a sign of type 2 diabetes or, less commonly, diabetes insipidus Urinary incontinence or a sudden urgency to urinate that is difficult to control Urination that continues to be very frequent (more than 8 times in 24 hours) beyond the initial weeks of dieting Persistently dark urine despite drinking adequate fluids (tea- or cola-coloured urine may suggest a kidney or liver problem) Persistently foamy urine , which may be a sign of protein in the urine (proteinuria) and warrants assessment Seek urgent medical attention (same day) if you experience: Excessive thirst, frequent urination, unexplained weight loss, nausea, vomiting, abdominal pain, drowsiness, or a fruity smell on the breath these can be signs of type 1 diabetes or diabetic ketoacidosis, which requires urgent assessment
Statements Author contributions TH: Supervision, Visualization, Writing original draft, Formal analysis, Software, Data curation, Funding acquisition, Methodology, Validation, Conceptualization, Resources, Investigation, Project administration, Writing review & editing
