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Furthermore, TMAO increased aortic plaque area and altered bile acid composition in male ApoE (-/-) mice, accelerating aortic lesions by modifying bile acid profiles, activating FXR and small heterodimer partner, and inhibiting bile acid synthesis (136)

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Proc Natl Acad Sci U S A 1992;89:86415.ArticlePubMedPMC 17

Advanced Dosing Protocol Experienced peptide users with established tolerance may utilize higher doses for maximum effect: Total daily dose : 600-1000mcg (300-500mcg each peptide) Frequency : 5-6 days per week Administration : Single evening dose or split AM/PM dosing Cycle length : 12-16 weeks followed by 4-8 week break Important note : Higher doses don't always equal better results