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Predrag Sikirics group (School of Medicine, University of Zagreb, 1991 ) Most common experimental dose in animal studies: 10 g/kg intraperitoneally or per os, daily Standard targeted pathways: VEGFR2 angiogenesis, NO synthase , 5-HT2A serotonin receptor, dopamine D2 receptor Clinical program in Croatia halted at Phase 2 (Crohns disease) WADA Prohibited List: added in 2022 to category S0 (Non-Approved Substances) Reference sources (PubMed) Sikiric P

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The brand's FAQ explicitly states that people with medical conditions or taking prescription medications should consult their doctor before use - and for this specific product, the drug interaction profile of L-Arginine and L-Citrulline with nitrate medications, antihypertensives, and PDE5 inhibitors makes that recommendation more than standard legal boilerplate