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So why do many patients still develop: Hand deformities Knee deformities Joint destruction Walking difficulty Muscle wasting Permanent disability Because modern arthritis care is not just about increasing medicines-it is about building the right strategy

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Membranes were incubated with primary antibody NFE2L2 (Ab62352, Abcam), GCLC (Ab 53179, Abcam), TMBIM1 (ab121358, Abcam), CLK2 (AP7530a, Abgent, San Diego, CA, USA) and -tubulin (T9026, SigmaAldrich, St