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With both tirzepatide and semaglutide, approximately 33-40% of total weight lost consists of lean mass

Exenatide and placebo groups were matched for age (mean (standard deviation (SD) age of exenatide group 28 (13) years, placebo group 28 (6) years) and body mass index (BMI) (exenatide group 37.6 (7.9) kg/m 2 , placebo group 38.6 (4.7) kg/m 2 )

The primary endpoints are improvements in body weight, waist circumference, and BMI measured in metric units to publish results across the world in a clear and comparable manner

For athletes or active individuals, its benefits lie primarily in fat mass reduction and appetite regulation , though it does not appear to preserve lean body mass to the same degree suggested in Tirzepatide trials