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Effects vary by individualearly titration phases carry higher risk than stable maintenance phases
Preserving skeletal muscle is essential for lasting results, as muscle loss significantly increases the risk of rebound weight gain
And the agency has warned about companies illegally selling unapproved products containing semaglutide, tirzepatide or retatrutide falsely labeled "for research purposes" or "not for human consumption." As of May 31, 2026, the FDA had received 990 adverse event reports associated with compounded semaglutide and more than 730 associated with compounded tirzepatide
