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10.1016/j.phrs.2014.10.009 [DOI] [PubMed] [Google Scholar] 423.Zahid, A

When the primary injury occurs, the cerebrovascular system vibrates and be torn due to the external force, leading to shedding of vascular endothelial cells and loosening of tight junctions between endothelial cells, resulting in increased BBB permeability, release of activated leukocytes, inflammatory factors, glial cells, and substances toxic to neurons into the brain parenchyma, causing inflammation and immune reactions [20]

If youre using medications for weight loss, aim for slow, consistent progress (0.5 to 1kg per week) to minimise the risk of excessive skin sagging