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31,34-36 Thirty years ago the standard of care for treating hyperlipidemia included a 3-month period of TLC prior to starting pharmacotherapy 37 , whereas, now lifestyle and pharmacotherapy are initiated simultaneously for hyperlipidemia, diabetes, hypertension, and most other chronic diseases other than overweight and obesity

(NEJM, 2023), Retatrutide achieved approximately 24% mean weight reduction at 12 mg at 48 weeks