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The available evidence points to complementary modes of action based on compounds that induce rapid mortality, combined with others exhibiting high potency at low doses, which may exert repellency or sustained-release activity to optimize efficacy, persistence, and environmental compatibility

In preclinical and in vitro research, L-carnitine is used to investigate mitochondrial fatty-acid -oxidation, the CPT-I/CPT-II carnitine palmitoyltransferase system, membrane transport via the OCTN2 carnitine transporter, and carnitine biosynthesis and homeostasis

Angiogenic signaling and macrophage recruitment have been proposed as contributing mechanisms

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