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plus budget-friendly generic alternatives like metformin and topiramate

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Nevertheless, oxyntomodulin can be cleaved by DPP-4 in vitro (36, 56), and in animal studies, the anorectic effects of exogenous oxyntomodulin are increased after DPP-4 inhibition (56), while DPP-4-resistant oxyntomodulin analogs have been associated with improved glucose tolerance, reduced food intake, greater energy expenditure, and weight loss (57, 58)

However, it is important to remember that dietary supplements alone cannot lead to significant weight loss, and they should be used in combination with a healthy diet and regular exercise