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Mediators of Inflammation

Exendin-4 significantly increased insulin level and phosphorylation of insulin receptor substrate 1 (IRS-1) in rat hippocampus, and could not change the status of tau phosphorylation without insulin in HT22 neurons, suggesting that insulin is required in reduction of tau hyperphosphorylation by GLP-1R agonists (154)

[1] [2] During the first month of semaglutide treatment, patients typically experience modest but noticeable weight loss as the medication is initiated at lower doses

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