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Reducing dosage and keep dosing frequency would make more sense due to the pk rationale I agree, particularly after several years, once habits regarding exercise, portion control and simply becoming more accustomed to some degree of hunger as being acceptable, I have found this effective

Consequently, the current clinical emphasis is on symptom alleviation, functional enhancement, and minimizing HF-related hospitalizations

10.4239/wjd.v14.i9.1349 112 SweetwyneM

While these medications can be incredible tools, they come with important responsibilities and one of the biggest is ensuring you consistently meet your protein goals