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Linking Alzheimers disease and type 2 diabetes mellitus via aberrant insulin signaling and inflammation

In rodent studies conducted during drug development, GLP-1 receptor agonists, including tirzepatide, were associated with an increased incidence of thyroid C-cell tumours (medullary thyroid carcinoma) in rats and mice

The method has the advantages that Fmoc-Lys (Alloc)-OH protection amino acid is used as a raw material, de-protection is carried out by the aid of selected Pd (PPh3) 4, accordingly, operation procedures are simple, only 1-2 times of simple elimination reaction operation are required, each elimination reaction operation is carried out for 10-30 min, side reaction is prevented, the operation procedures are safe, and enlarged production can be facilitated

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