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These encompass the leptin-melanocortin trajectory, the opioid schema, the system involving glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R), and the axis of fibroblast growth factor 21 (FGF21) along with its receptor complex FGFR1c/ -klotho [13]

Consequently, persistent high blood sugar ultimately results in prediabetes and type II diabetes

We reasoned that stimulation of glucose transport would have an impact on the rate of glycolysis as reflected by lactate release and if so, would provide a demonstration this novel effect of Y1R agonism on muscle based on the results of two different assay systems

CLP through activating Nrf2 signaling pathway and increased antioxidant oxidase content regulated HFHS diet-induced insulin resistance, offers the possibility that the CLP can be used as a treatment for diabetes