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For instance, elevated ROS may oxidize the highly-conserved, active site Cys residue of mitogen-activated protein kinase phosphatases [106, 107], resulting in persistent activation (phosphorylation) of mitogen-activated protein kinases such as JNK and p38 kinase, contributing to MDMA-induced apoptosis/necrosis

In Prp-TDP-43 A315T mice, dysregulated expression of estrogen-related enzymes (CYP19A1 and CYP3A4) was observed relative to wild-type controls, which suggested that toxic phosphorylated TDP-43 oligomers may disrupt the balance between CYP19A1 and CYP3A4 expression, resulting in reduced estrogen biosynthesis and accelerated degradation

Arterburn DE, Telem DA, Kushner RF, Courcoulas AP