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Conclusion The present review has summarized the current clinical evidence for a potential use of GLP-1R agonists in prospective neuroprotective treatment strategies against glaucoma and other neurodegenerative diseases

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However, with low levels of the rate-limiting synthesis enzyme (glutamate-cysteine ligase) and low levels of GSH, lithium and valproate neuroprotective effects are inhibited, which indicates that adequate GSH levels could be important for efficacy (227, 228)