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This creates a rational decision for IP teams: reduce investment in late-stage secondary patent filings for small-molecule drugs and redirect that IP budget toward earlier-stage patents (where the compound is still within its pre-negotiation window) or toward biologic assets (where the 13-year clock preserves the value of secondary patents in years 9-13)

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Common side effects include nausea and vomiting (slightly more common with the pill version), diarrhoea and/or constipation and abdominal discomfort, but these generally settle once people get used to the medicine