Additionally, we find that the decrease in glutamate brought by acivicin could be rescued by administration of pyroglutamate (5-oxoproline), a downstream metabolite in the glutathione pathway that is a precursor of glutamate (Fig
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3 Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical Sciences, Pozna, Poland Correspondence: Karolina Hoffmann, Department and Clinic of Internal Diseases and Metabolic Disorders, Poznan University of Medical Sciences, Przybyszewskiego 49 Street, 60-355, Pozna, Poland, Tel +4861 8549 377, Fax +4861 8478 529, Email [email protected] Purpose: To compare the efficacy and safety of semaglutide and liraglutide over one year in obese Polish patients with type 2 diabetes