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In addition to excretion of waste nitrogen, urea secretion is coupled to the regulation of the urine concentrating properties of the nephron, specifically within the collecting duct portion of the nephron (specifically the inner medullary collecting duct, IMCD)

This could be a potential confounding factor that might influence the observed hematological outcomes

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By comparing these peptides in laboratory environments, researchers can better understand how localized and systemic growth pathways interact